Monitoring Drug Abuse in South Africa
Monitoring Drug Abuse in the SADC region

fact sheet on over-the-counter (otc) and prescription medicine misuse
Prepared by:
Alcohol and Drug Abuse Research Group, Medical Research Council

Supported by UNDCP Global Assessment Programme (GAP) on Drug Abuse
Commonly misused otc and presciption medicines

  • Benzodiazepines and analgesics are two of the most widely misused classes of licit medicines.
  • Benzodiazepines are sedative-hypnotics that act as central nervous system (CNS) depressants.
  • When used appropriately, they are effective in treating a range of medical conditions, including anxiety disorders, insomnia, convulsive disorders, and involuntary movement disorders.
  • Benzodiazepines are only available through prescription.
  • Prescription and OTC analgesics are effective in the treatment and management of both short-and long-term pain.
  • Analgesics can be broadly grouped into two categories: opioid analgesics (e.g. codeine and morphine) and non-narcotic analgesics that include non-steroidal anti-inflammatory drugs.

Effects of misuse

  • Benzodiazepine misuse may result in transient side effects, including psychomotor retardation, cognitive dysfunction, disinhibition, and emotional blunting.
  • The misuse of benzodiazepines together with other CNS depressants (e.g. alcohol and heroin) places the user at risk for overdose and death.
  • A long-term consequence of benzodiazepine misuse is psychological and physical dependence, with a distinctive benzodiazepine withdrawal syndrome occurring on cessation of use.
  • Analgesic misuse is associated with numerous negative health outcomes.
  • Opioid analgesics act as CNS depressants. Large doses may result in respiratory suppression, seizures, coma, and potentially death.
  • A long-term health outcome of opioid analgesic misuse is psychological and physiological dependence.
  • The chronic misuse of non-narcotic analgesics is associated with headaches, gastro-intestinal problems such as ulcers, analgesic nephropathy including renal failure and renal cancers, and atherogenesis.

For current statistics visit our SACENDU site.

Last updated:
30-Oct-2008

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Yolanda.Williams@mrc.ac.za

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